Eyal Kimchi Lab

Our consciousness and awareness depend upon a intricate balance both between brain networks. For over 20% of hospitalized older adults, this neural balance is disrupted, resulting in delirium. Despite delirium being the most common neuropsychiatric condition in the hospital, it remains underrecognized, poorly understood, and lacks FDA approved therapies.

We study brain networks and neural rhythms that support clear thinking, with a goal of preventing and treating acute alterations of attention and awareness. Our research is informed by clinical experience and inspired by our patients. Our team leads translationally relevant basic science research, acute clinical research, and provides clinical care.

Basic Research

We study how neuromodulators such as acetylcholine and systemic factors such as inflammation influence the function of neural networks critical for attention and awareness. Our translational work is motivated by our desire to understand the pathophysiology of delirium. Our models are rigorously validated using state-of-the-art clinical research scales and neurophysiology.

Brain swirl

Clinical Research

We lead clinical research in patients to predict who will develop delirium and how we can prevent and treat it. Our work leverages wearable technology to measure brain activity noninvasively and continuously. We employ AI analyses to discover new biomarkers that track and predict the course of delirium.

Clinical care

We provide clinical care to patients with delirium and other acute neurologic illnesses through the inpatient neurology services at Northwestern Memorial Hospital